Why are Klinefelter patients tall?

Why are Klinefelter patients tall?

Why are Klinefelter patients tall?

From early school age, boys with Klinefelter's syndrome tend to be taller (increased leg length) because testosterone normally stops boys growing after puberty. This increase in height is maintained throughout life. Patients with Klinefelter's syndrome may have reduced coordination compared with other boys.

Can you be short with Klinefelter syndrome?

Three main clinical signs should suggest the diagnosis in a child: small testes, tall stature, and mental retardation or learning problems. We present a patient with Klinefelter syndrome and short stature due to growth hormone deficiency. His height was below the third percentile for age and his bone age delayed.

Why do Klinefelter have small testes?

Testicular biopsy specimens of infants with this disorder reveal only a reduced number of germ cells19; after the onset of puberty, however, the pathologic changes characteristic of KS such as hyalinization and fibrosis of the seminiferous tubules appear, leading to small, shrunken testes and azoospermia.

Do all people with Klinefelter syndrome have small testes?

Boys and men with Klinefelter syndrome typically have small testes that produce a reduced amount of testosterone (primary testicular insufficiency). Testosterone is the hormone that directs male sexual development before birth and during puberty.

How tall are people with Klinefelter?

Adults with Klinefelter syndrome are usually taller than nonaffected adult males, reaching a mean final height of about 185 cm (73 in). XXY males (see the image below) also have disproportionately long arms and legs. About 25% of patients have fifth-finger clinodactyly.

What does a person with Klinefelter syndrome look like?

Longer legs, shorter torso and broader hips compared with other boys. Absent, delayed or incomplete puberty. After puberty, less muscle and less facial and body hair compared with other teens. Small, firm testicles.

Can Klinefelter cause gynecomastia?

Klinefelter syndrome is usually diagnosed in puberty when the clinical features become most apparent. These include gynecomastia, eunuchoid body proportions, sparse facial and pubertal hair, and small firm testes. Gynecomastia results from a decreased testosterone to estradiol ratio.

What is the survival rate of Klinefelter syndrome?

We found that Klinefelter syndrome was associated with a significant increase in mortality risk of 40% (hazard ratio, 1.

What does Klinefelter syndrome mean for men and women?

Klinefelter syndrome is a very specific health condition with extra female chromosome (so called “XXY syndrome”) – condition that occurs in men who have an extra X chromosome.

Can a male with Klinefelter syndrome have breast growth?

In some cases, breast growth can be permanent, and about 10% of XXY males need breast-reduction surgery. 6 Most males with KS have normal intelligence quotients (IQs) 7, 8 and successfully complete education at all levels. (IQ is a frequently used intelligence measure, but does not include emotional, creative, or other types of intelligence.)

What are the symptoms of POLY-X Klinefelter syndrome?

Symptoms of Poly-X KS. Males with poly-X Klinefelter syndrome have more than one extra X chromosome, so their symptoms might be more pronounced than in males with KS. In childhood, they may also have seizures, crossed eyes, constipation, and recurrent ear infections.

What are the causes of Mosaic Klinefelter syndrome?

Klinefelter syndrome can be caused by: 1 One extra copy of the X chromosome in each cell (XXY), the most common cause 2 An extra X chromosome in some of the cells (mosaic Klinefelter syndrome), with fewer symptoms 3 More than one extra copy of the X chromosome, which is rare and results in a severe form

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